Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis

Abstract Introduction Clinical studies suggest a direct influence of periodontal disease (PD) on serum inflammatory markers and disease assessment of patients with established rheumatoid arthritis (RA). However, the influence of PD on arthritis development remains unclear. This investigation was undertaken to determine the contribution of chronic PD to immune activation and development of joint inflammation using the collagen-induced arthritis (CIA) model. Methods DBA1/J mice orally infected with Porphyromonas gingivalis were administered with collagen II (CII) emulsified in complete Freund’s adjuvant (CFA) or incomplete Freund’s adjuvant (IFA) to induce arthritis. Arthritis development was assessed by visual scoring of paw swelling, caliper measurement of the paws, mRNA expression, paw micro-computed tomography (micro-CT) analysis, histology, and tartrate resistant acid phosphatase for osteoclast detection (TRAP)-positive immunohistochemistry. Serum and reactivated splenocytes were evaluated for cytokine expression. Results Mice induced for PD and/or arthritis developed periodontal disease, shown by decreased alveolar bone and alteration of mRNA expression in gingival tissues and submandibular lymph nodes compared to vehicle. P. gingivalis oral infection increased paw swelling and osteoclast numbers in mice immunized with CFA/CII. Arthritis incidence and severity were increased by P. gingivalis in mice that received IFA/CII immunizations. Increased synovitis, bone erosions, and osteoclast numbers in the paws were observed following IFA/CII immunizations in mice infected with P gingivalis. Furthermore, cytokine analysis showed a trend toward increased serum Th17/Th1 ratios when P. gingivalis infection was present in mice receiving either CFA/CII or IFA/CII immunizations. Significant cytokine increases induced by P. gingivalis oral infection were mostly associated to Th17-related cytokines of reactivated splenic cells, including IL-1β, IL-6, and IL-22 in the CFA/CII group and IL-1β, tumor necrosis factor-α, transforming growth factor-β, IL-6 and IL-23 in the IFA/CII group. Conclusions Chronic P. gingivalis oral infection prior to arthritis induction increases the immune system activation favoring Th17 cell responses, and ultimately accelerating arthritis development. These results suggest that chronic oral infection may influence RA development mainly through activation of Th17-related pathways.http://deepblue.lib.umich.edu/bitstream/2027.42/112639/1/13075_2013_Article_4062.pd

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response

Functional genomics efforts face tradeoffs between number of perturbations examined and complexity of phenotypes measured. We bridge this gap with Perturb-seq, which combines droplet-based single-cell RNA-seq with a strategy for barcoding CRISPR-mediated perturbations, allowing many perturbations to be profiled in pooled format. We applied Perturb-seq to dissect the mammalian unfolded protein response (UPR) using single and combinatorial CRISPR perturbations. Two genome-scale CRISPR interference (CRISPRi) screens identified genes whose repression perturbs ER homeostasis. Subjecting ∼100 hits to Perturb-seq enabled high-precision functional clustering of genes. Single-cell analyses decoupled the three UPR branches, revealed bifurcated UPR branch activation among cells subject to the same perturbation, and uncovered differential activation of the branches across hits, including an isolated feedback loop between the translocon and IRE1α. These studies provide insight into how the three sensors of ER homeostasis monitor distinct types of stress and highlight the ability of Perturb-seq to dissect complex cellular responses.National Human Genome Research Institute (U.S.) (Grant P50HG006193

Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy

BACKGROUND: Cancer therapy-induced cardiomyopathy (CCM) is associated with cumulative drug exposures and preexisting cardiovascular disorders. These parameters incompletely account for substantial interindividual susceptibility to CCM. We hypothesized that rare variants in cardiomyopathy genes contribute to CCM. METHODS: We studied 213 patients with CCM from 3 cohorts: retrospectively recruited adults with diverse cancers (n=99), prospectively phenotyped adults with breast cancer (n=73), and prospectively phenotyped children with acute myeloid leukemia (n=41). Cardiomyopathy genes, including 9 prespecified genes, were sequenced. The prevalence of rare variants was compared between CCM cohorts and The Cancer Genome Atlas participants (n=2053), healthy volunteers (n=445), and an ancestry-matched reference population. Clinical characteristics and outcomes were assessed and stratified by genotypes. A prevalent CCM genotype was modeled in anthracycline-treated mice. RESULTS: CCM was diagnosed 0.4 to 9 years after chemotherapy; 90% of these patients received anthracyclines. Adult patients with CCM had cardiovascular risk factors similar to the US population. Among 9 prioritized genes, patients with CCM had more rare protein-altering variants than comparative cohorts ( P≤1.98e-04). Titin-truncating variants (TTNtvs) predominated, occurring in 7.5% of patients with CCM versus 1.1% of The Cancer Genome Atlas participants ( P=7.36e-08), 0.7% of healthy volunteers ( P=3.42e-06), and 0.6% of the reference population ( P=5.87e-14). Adult patients who had CCM with TTNtvs experienced more heart failure and atrial fibrillation ( P=0.003) and impaired myocardial recovery ( P=0.03) than those without. Consistent with human data, anthracycline-treated TTNtv mice and isolated TTNtv cardiomyocytes showed sustained contractile dysfunction unlike wild-type ( P=0.0004 and P<0.002, respectively). CONCLUSIONS: Unrecognized rare variants in cardiomyopathy-associated genes, particularly TTNtvs, increased the risk for CCM in children and adults, and adverse cardiac events in adults. Genotype, along with cumulative chemotherapy dosage and traditional cardiovascular risk factors, improves the identification of patients who have cancer at highest risk for CCM. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifiers: NCT01173341; AAML1031; NCT01371981.This work was supported in part by grants from the Instituto de Salud Carlos III (ISCIII) (PI15/01551, PI17/01941 and CB16/11/00432 to P.G-P. and L.A-P.), the Spanish Ministry of Economy and Competitiveness (SAF2015-71863-REDT to P.G-P.), the John S. LaDue Memorial Fellowship at Harvard Medical School (Y.K.), Wellcome Trust (107469/Z/15/Z to J.S.W.), Medical Research Council (intramural awards to S.A.C. and J.S.W; MR/M003191/1 to U.T), National Institute for Health Research Biomedical Research Unit at the Royal Brompton and Harefield National Health Service Foundation Trust and Imperial College London (P.J.B., S.A.C., J.S.W.), National Institute for Health Research Biomedical Research Centre at Imperial College London Healthcare National Health Service Trust and Imperial College London (D.O.R., S.A.C., S.P., J.S.W.), Sir Henry Wellcome Postdoctoral Fellowship (C.N.T.), Rosetrees and Stoneygate Imperial College Research Fellowship (N.W.), Fondation Leducq (S.A.C., C.E.S., J.G.S.), Health Innovation Challenge Fund award from the Wellcome Trust and Department of Health (UK; HICF-R6-373; S.A.C., P.J.B., J.S. W.), the British Heart Foundation (NH/17/1/32725 to D.O.R.; SP/10/10/28431 to S.A.C), Alex’s Lemonade Stand Foundation (K.G.), National Institutes of Health (R.A.: U01CA097452, R01CA133881, and U01CA097452; Z.A.: R01 HL126797; B.K.: R01 HL118018 and K23-HL095661; J.G.S. and C.E.S.: 5R01HL080494, R01HL084553), and the Howard Hughes Medical Institute (C.E.S.). The Universitario Puerta de Hierro and Virgen de la Arrixaca Hospitals are members of the European Reference Network on Rare and Complex Diseases of the Heart (Guard-Heart; http://guard-heart.ern-net.eu). This publication includes independent research commissioned by the Health Innovation Challenge Fund (HICF), a parallel funding partnership between the Department of Health and Wellcome Trust. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Ministry of Economy, Industry and Competitiveness and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-2015-0505). Grants from ISCIII and the Spanish Ministry of Economy and Competitiveness are supported by the Plan Estatal de I+D+I 2013-2016 – European Regional Development Fund (FEDER) “A way of making Europe”.S

Joint Constraints on Galactic Diffuse Neutrino Emission from the ANTARES and IceCube Neutrino Telescopes

[EN] The existence of diffuse Galactic neutrino production is expected from cosmic-ray interactions with Galactic gas and radiation ¿elds. Thus, neutrinos are a unique messenger offering the opportunity to test the products of Galactic cosmic-ray interactions up to energies of hundreds of TeV. Here we present a search for this production using ten years of Astronomy with a Neutrino Telescope and Abyss environmental RESearch (ANTARES) track and shower data, as well as seven years of IceCube track data. The data are combined into a joint likelihood test for neutrino emission according to the KRAg model assuming a 5 PeV per nucleon Galactic cosmic-ray cutoff. No signi¿cant excess is found. As a consequence, the limits presented in this Letter start constraining the model parameter space for Galactic cosmic-ray production and transport.Albert, A.; Andre, M.; Anghinolfi, M.; Ardid Ramírez, M.; Aubert, J-.; Aublin, J.; Avgitas, T.... (2018). Joint Constraints on Galactic Diffuse Neutrino Emission from the ANTARES and IceCube Neutrino Telescopes. The Astrophysical Journal. 868(2):1-7. https://doi.org/10.3847/2041-8213/aaeecfS178682Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Anderson, T. (2017). Search for Astrophysical Sources of Neutrinos Using Cascade Events in IceCube. The Astrophysical Journal, 846(2), 136. doi:10.3847/1538-4357/aa8508Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., … Archinger, M. (2015). A COMBINED MAXIMUM-LIKELIHOOD ANALYSIS OF THE HIGH-ENERGY ASTROPHYSICAL NEUTRINO FLUX MEASURED WITH ICECUBE. The Astrophysical Journal, 809(1), 98. doi:10.1088/0004-637x/809/1/98Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., … Anderson, T. (2017). All-sky Search for Time-integrated Neutrino Emission from Astrophysical Sources with 7 yr of IceCube Data. The Astrophysical Journal, 835(2), 151. doi:10.3847/1538-4357/835/2/151Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Anderson, T. (2017). Constraints on Galactic Neutrino Emission with Seven Years of IceCube Data. The Astrophysical Journal, 849(1), 67. doi:10.3847/1538-4357/aa8dfbAartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Ansseau, I. (2017). The IceCube Neutrino Observatory: instrumentation and online systems. Journal of Instrumentation, 12(03), P03012-P03012. doi:10.1088/1748-0221/12/03/p03012Ackermann, M., Ajello, M., Atwood, W. B., Baldini, L., Ballet, J., Barbiellini, G., … Berenji, B. (2012). FERMI-LAT OBSERVATIONS OF THE DIFFUSE γ-RAY EMISSION: IMPLICATIONS FOR COSMIC RAYS AND THE INTERSTELLAR MEDIUM. The Astrophysical Journal, 750(1), 3. doi:10.1088/0004-637x/750/1/3Adrián-Martínez, S., Ageron, M., Aguilar, J. A., Samarai, I. A., Albert, A., André, M., … Ardid, M. (2012). The positioning system of the ANTARES Neutrino Telescope. Journal of Instrumentation, 7(08), T08002-T08002. doi:10.1088/1748-0221/7/08/t08002Ageron, M., Aguilar, J. A., Al Samarai, I., Albert, A., Ameli, F., André, M., … Ardid, M. (2011). ANTARES: The first undersea neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 656(1), 11-38. doi:10.1016/j.nima.2011.06.103Ahn, H. S., Allison, P., Bagliesi, M. G., Beatty, J. J., Bigongiari, G., Childers, J. T., … Zinn, S. Y. (2010). DISCREPANT HARDENING OBSERVED IN COSMIC-RAY ELEMENTAL SPECTRA. The Astrophysical Journal, 714(1), L89-L93. doi:10.1088/2041-8205/714/1/l89Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). New constraints on all flavor Galactic diffuse neutrino emission with the ANTARES telescope. Physical Review D, 96(6). doi:10.1103/physrevd.96.062001Antoni, T., Apel, W. D., Badea, A. F., Bekk, K., Bercuci, A., Blümer, J., … Zabierowski, J. (2005). KASCADE measurements of energy spectra for elemental groups of cosmic rays: Results and open problems. Astroparticle Physics, 24(1-2), 1-25. doi:10.1016/j.astropartphys.2005.04.001Apel, W. D., Arteaga-Velázquez, J. C., Bekk, K., Bertaina, M., Blümer, J., Bozdog, H., … Cossavella, F. (2013). KASCADE-Grande measurements of energy spectra for elemental groups of cosmic rays. Astroparticle Physics, 47, 54-66. doi:10.1016/j.astropartphys.2013.06.004Gaggero, D., Grasso, D., Marinelli, A., Taoso, M., & Urbano, A. (2017). Diffuse Cosmic Rays Shining in the Galactic Center: A Novel Interpretation of H.E.S.S. and Fermi-LAT γ -Ray Data. Physical Review Letters, 119(3). doi:10.1103/physrevlett.119.031101Gaggero, D., Grasso, D., Marinelli, A., Urbano, A., & Valli, M. (2015). THE GAMMA-RAY AND NEUTRINO SKY: A CONSISTENT PICTURE OF FERMI -LAT, MILAGRO, AND ICECUBE RESULTS. The Astrophysical Journal, 815(2), L25. doi:10.1088/2041-8205/815/2/l25Gaggero, D., Urbano, A., Valli, M., & Ullio, P. (2015). Gamma-ray sky points to radial gradients in cosmic-ray transport. Physical Review D, 91(8). doi:10.1103/physrevd.91.083012Vladimirov, A. E., Digel, S. W., Jóhannesson, G., Michelson, P. F., Moskalenko, I. V., Nolan, P. L., … Strong, A. W. (2011). GALPROP WebRun: An internet-based service for calculating galactic cosmic ray propagation and associated photon emissions. Computer Physics Communications, 182(5), 1156-1161. doi:10.1016/j.cpc.2011.01.01

ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky

[EN] A search for point-like and extended sources of cosmic neutrinos using data collected by the ANTARES and IceCube neutrino telescopes is presented. The data set consists of all the track-like and shower-like events pointing in the direction of the Southern Sky included in the nine-year ANTARES point-source analysis, combined with the throughgoing track-like events used in the seven-year IceCube point-source search. The advantageous ¿eld of view of ANTARES and the large size of IceCube are exploited to improve the sensitivity in the Southern Sky by a factor of ~2 compared to both individual analyses. In this work, the Southern Sky is scanned for possible excesses of spatial clustering, and the positions of preselected candidate sources are investigated. In addition, special focus is given to the region around the Galactic Center, whereby a dedicated search at the location of SgrA* is performed, and to the location of the supernova remnant RXJ 1713.7-3946. No signi¿cant evidence for cosmic neutrino sources is found, and upper limits on the ¿ux from the various searches are presented.The authors of the IceCube Collaboration acknowledge the support from the following agencies and institutions: USA-U.S. National Science Foundation-Office of Polar Programs, U.S. National Science Foundation-Physics Division, Wisconsin Alumni Research Foundation, Center for High Throughput Computing (CHTC) at the University of Wisconsin-Madison, Open Science Grid (OSG), Extreme Science and Engineering Discovery Environment (XSEDE), U.S. Department of Energy-National Energy Research Scientific Computing Center, Particle astrophysics research computing center at the University of Maryland, Institute for Cyber-Enabled Research at Michigan State University, and Astroparticle physics computational facility at Marquette University; Belgium-Funds for Scientific Research (FRS-FNRS and FWO), FWO Odysseus and Big Science programmes, and Belgian Federal Science Policy Office (Belspo); Germany-Bundesministerium fur Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Helmholtz Alliance for Astroparticle Physics (HAP), Initiative and Networking Fund of the Helmholtz Association, Deutsches Elektronen Synchrotron (DESY), and High Performance Computing Cluster of the RWTH Aachen; Sweden-Swedish Research Council, Swedish Polar Research Secretariat, Swedish National Infrastructure for Computing (SNIC), and Knut and Alice Wallenberg Foundation; Australia - Australian Research Council; Canada-Natural Sciences and Engineering Research Council of Canada, Calcul Quebec, Compute Ontario, Canada Foundation for Innovation, WestGrid, and Compute Canada; Denmark-Villum Fonden, Danish National Research Foundation (DNRF), Carlsberg Foundation; New Zealand-Marsden Fund; Japan-Japan Society for Promotion of Science (JSPS) and Institute for Global Prominent Research (IGPR) of Chiba University; Korea-National Research Foundation of Korea (NRF); Switzerland-Swiss National Science Foundation (SNSF); United Kingdom-Department of Physics, University of Oxford.Albert, A.; Andre, M.; Anghinolfi, M.; Anton, G.; Ardid Ramírez, M.; Aubert, J.; Aublin, J.... (2020). ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky. The Astrophysical Journal. 892(2):1-12. https://doi.org/10.3847/1538-4357/ab7afbS112892

Combined search for neutrinos from dark matter self-annihilation in the Galactic Center with ANTARES and IceCube

[EN] We present the results of the first combined dark matter search targeting the Galactic Center using the ANTARES and IceCube neutrino telescopes. For dark matter particles with masses from 50 to 1000 GeV, the sensitivities on the self-annihilation cross section set by ANTARES and IceCube are comparable, making this mass range particularly interesting for a joint analysis. Dark matter self-annihilation through the ¿+¿¿, ¿+¿¿, b¯b, and W+W¿ channels is considered for both the Navarro-Frenk-White and Burkert halo profiles. In the combination of 2101.6 days of ANTARES data and 1007 days of IceCube data, no excess over the expected background is observed. Limits on the thermally averaged dark matter annihilation cross section h¿A¿i are set. These limits present an improvement of up to a factor of 2 in the studied dark matter mass range with respect to the individual limits published by both collaborations. When considering dark matter particles with a mass of 200 GeV annihilating through the ¿þ¿¿ channel, the value obtained for the limit is 7.44 × 10¿24 cm3 s¿1 for the Navarro-Frenk-White halo profile. For the purpose of this joint analysis, the model parameters and the likelihood are unified, providing a benchmark for forthcoming dark matter searches performed by neutrino telescopes.The authors from the ANTARES Collaboration acknowledge the financial support of the following funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et auxenergies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Junta de Andalucia (ref. SOMM17/6104/UGR), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and CC-IN2P3 for the computing facilities. The authors from the IceCube Collaboration gratefully acknowledge the support from the following agencies and institutions: USA-U.S. National Science Foundation-Office of Polar Programs, U.S. National Science Foundation-Physics Division, Wisconsin Alumni Research Foundation, Center for High Throughput Computing (CHTC) at the University of Wisconsin-Madison, Open Science Grid (OSG), Extreme Science and Engineering Discovery Environment (XSEDE), U.S. Department of Energy-National Energy Research Scientific Computing Center, Particle astrophysics research computing center at the University of Maryland, Institute for Cyber-Enabled Research at Michigan State University, and Astroparticle physics computational facility at Marquette University; Belgium-Funds for Scientific Research (FRS-FNRS and FWO), FWO Odysseus and Big Science programmes, and Belgian Federal Science Policy Office (Belspo); Germany-Bundesministerium fur Bildung und Forschung (BMBF), Deutsche Forschungsgemeinschaft (DFG), Helmholtz Alliance for Astroparticle Physics (HAP), Initiative and Networking Fund of the Helmholtz Association, Germany-Deutsches Elektronen Synchrotron (DESY), and High Performance Computing cluster of the RWTH Aachen; Sweden-Swedish Research Council, Swedish Polar Research Secretariat, Swedish National Infrastructure for Computing (SNIC), and Knut and Alice Wallenberg Foundation; Australia-Australian Research Council; Canada-Natural Sciences and Engineering Research Council of Canada, Calcul Quebec, Compute Ontario, Canada Foundation for Innovation, WestGrid, and Compute Canada; Denmark-Villum Fonden, Danish National Research Foundation (DNRF), Carlsberg Foundation; New Zealand-Marsden Fund; Japan-Japan Society for Promotion of Science (JSPS) and Institute for Global Prominent Research (IGPR) of Chiba University; Korea-National Research Foundation of Korea (NRF); Switzerland-Swiss National Science Foundation (SNSF); United Kingdom-Department of Physics, University of Oxford. The IceCube collaboration acknowledges the significant contributions to this manuscript from Sebastian Baur, Nadege Iovine and Sara Rebecca Gozzini.Albert, A.; Andre, M.; Anghinolfi, M.; Ardid Ramírez, M.; Aubert, J.; Aublin, J.; Baret, B.... (2020). Combined search for neutrinos from dark matter self-annihilation in the Galactic Center with ANTARES and IceCube. Physical Review D: covering particles, fields, gravitation, and cosmology. 102(8):1-13. https://doi.org/10.1103/PhysRevD.102.082002S113102

The search for high-energy neutrinos coincident with fast radio bursts with the ANTARES neutrino telescope

[EN] In the past decade, a new class of bright transient radio sources with millisecond duration has been discovered. The origin of these so-called fast radio bursts (FRBs) is still a mystery, despite the growing observational efforts made by various multiwavelength and multimessenger facilities. To date, many models have been proposed to explain FRBs, but neither the progenitors nor the radiative and the particle acceleration processes at work have been clearly identified. In this paper, we assess whether hadronic processes may occur in the vicinity of the FRB source. If they do, FRBs may contribute to the high-energy cosmic-ray and neutrino fluxes. A search for these hadronic signatures was carried out using the ANTARES neutrino telescope. The analysis consists in looking for high-energy neutrinos, in the TeV-PeV regime, that are spatially and temporally coincident with the detected FRBs. Most of the FRBs discovered in the period 2013-2017 were in the field of view of the ANTARES detector, which is sensitive mostly to events originating from the Southern hemisphere. From this period, 12 FRBs were selected and no coincident neutrino candidate was observed. Upper limits on the per-burst neutrino fluence were derived using a power-law spectrum, dN/DE nu proportional to E-nu(-gamma), for the incoming neutrino flux, assuming spectral indexes gamma = 1.0, 2.0, 2.5. Finally, the neutrino energy was constrained by computing the total energy radiated in neutrinos, assuming different distances for the FRBs. Constraints on the neutrino fluence and on the energy released were derived from the associated null results.The authors acknowledge financial support from the following funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat a l'energie atomique et aux energies alternatives (CEA), Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France (IUF), IdEx program and UnivEarthS Labex program at Sorbonne Paris Cite (ANR-10-LABX-0023 and ANR-11-IDEX-0005-02), Labex OCEVU (ANR-11-LABX-0060) and the A*MIDEX project (ANR-11-IDEX-0001-02), Region Ile-de-France (DIM-ACAV), Region Alsace (contrat CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Economia y Competitividad (MINECO): Plan Estatal de Investigacion (refs. FPA2015-65150-C3-1-P, -2-P and -3-P, (MINECO/FEDER)), Severo Ochoa Centre of Excellence and MultiDark Consolider (MINECO), and Prometeo and Grisolia programs (Generalitat Valenciana), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge technical support from Ifremer, AIM and Foselev Marine for the sea operation and CC-IN2P3 for the computing facilities.Albert, A.; Andre, M.; Anghinolfi, M.; Anton, G.; Ardid Ramírez, M.; Aubert, J.; Aublin, J.... (2019). The search for high-energy neutrinos coincident with fast radio bursts with the ANTARES neutrino telescope. Monthly Notices of the Royal Astronomical Society. 482(1):184-193. https://doi.org/10.1093/mnras/sty2621S1841934821Aartsen, M. G., Abbasi, R., Abdou, Y., Ackermann, M., Adams, J., Aguilar, J. A., … Bai, X. (2013). First Observation of PeV-Energy Neutrinos with IceCube. Physical Review Letters, 111(2). doi:10.1103/physrevlett.111.021103Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Arlen, T. C. (2015). Atmospheric and astrophysical neutrinos above 1 TeV interacting in IceCube. Physical Review D, 91(2). doi:10.1103/physrevd.91.022001Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., … Archinger, M. (2015). A COMBINED MAXIMUM-LIKELIHOOD ANALYSIS OF THE HIGH-ENERGY ASTROPHYSICAL NEUTRINO FLUX MEASURED WITH ICECUBE. The Astrophysical Journal, 809(1), 98. doi:10.1088/0004-637x/809/1/98Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Arlen, T. C. (2015). SEARCH FOR PROMPT NEUTRINO EMISSION FROM GAMMA-RAY BURSTS WITH ICECUBE. The Astrophysical Journal, 805(1), L5. doi:10.1088/2041-8205/805/1/l5Aartsen, M. G., Abraham, K., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., … Anderson, T. (2016). OBSERVATION AND CHARACTERIZATION OF A COSMIC MUON NEUTRINO FLUX FROM THE NORTHERN HEMISPHERE USING SIX YEARS OF ICECUBE DATA. The Astrophysical Journal, 833(1), 3. doi:10.3847/0004-637x/833/1/3Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Anderson, T. (2018). A Search for Neutrino Emission from Fast Radio Bursts with Six Years of IceCube Data. The Astrophysical Journal, 857(2), 117. doi:10.3847/1538-4357/aab4f8Abbott, B. P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., … Adya, V. B. (2017). GW170817: Observation of Gravitational Waves from a Binary Neutron Star Inspiral. Physical Review Letters, 119(16). doi:10.1103/physrevlett.119.161101Abbott, B. P., Abbott, R., Abbott, T. D., Acernese, F., Ackley, K., Adams, C., … Adya, V. B. (2017). Gravitational Waves and Gamma-Rays from a Binary Neutron Star Merger: GW170817 and GRB 170817A. The Astrophysical Journal, 848(2), L13. doi:10.3847/2041-8213/aa920cAdrián-Martínez, S., Al Samarai, I., Albert, A., André, M., Anghinolfi, M., Anton, G., … Aubert, J.-J. (2012). SEARCH FOR COSMIC NEUTRINO POINT SOURCES WITH FOUR YEARS OF DATA FROM THE ANTARES TELESCOPE. The Astrophysical Journal, 760(1), 53. doi:10.1088/0004-637x/760/1/53Adrián-Martínez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Ameli, F., … Anghinolfi, M. (2016). Letter of intent for KM3NeT 2.0. Journal of Physics G: Nuclear and Particle Physics, 43(8), 084001. doi:10.1088/0954-3899/43/8/084001Ageron, M., Aguilar, J. A., Al Samarai, I., Albert, A., Ameli, F., André, M., … Ardid, M. (2011). ANTARES: The first undersea neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 656(1), 11-38. doi:10.1016/j.nima.2011.06.103Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). All-sky search for high-energy neutrinos from gravitational wave event GW170104 with the Antares neutrino telescope. The European Physical Journal C, 77(12). doi:10.1140/epjc/s10052-017-5451-zAlbert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). First all-flavor neutrino pointlike source search with the ANTARES neutrino telescope. Physical Review D, 96(8). doi:10.1103/physrevd.96.082001Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). Search for high-energy neutrinos from bright GRBs with ANTARES. Monthly Notices of the Royal Astronomical Society, 469(1), 906-915. doi:10.1093/mnras/stx902Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Barrios-Martí, J. (2018). All-flavor Search for a Diffuse Flux of Cosmic Neutrinos with Nine Years of ANTARES Data. The Astrophysical Journal, 853(1), L7. doi:10.3847/2041-8213/aaa4f6Bailes, M., Jameson, A., Flynn, C., Bateman, T., Barr, E. D., Bhandari, S., … Temby, D. (2017). The UTMOST: A Hybrid Digital Signal Processor Transforms the Molonglo Observatory Synthesis Telescope. Publications of the Astronomical Society of Australia, 34. doi:10.1017/pasa.2017.39Bannister, K. W., Shannon, R. M., Macquart, J.-P., Flynn, C., Edwards, P. G., O’Neill, M., … Clarke, N. (2017). The Detection of an Extremely Bright Fast Radio Burst in a Phased Array Feed Survey. The Astrophysical Journal, 841(1), L12. doi:10.3847/2041-8213/aa71ffBhandari, S., Keane, E. F., Barr, E. D., Jameson, A., Petroff, E., Johnston, S., … Burke-Spolaor, S. (2017). The SUrvey for Pulsars and Extragalactic Radio Bursts – II. New FRB discoveries and their follow-up. Monthly Notices of the Royal Astronomical Society, 475(2), 1427-1446. doi:10.1093/mnras/stx3074Biehl, D., Heinze, J., & Winter, W. (2018). Expected neutrino fluence from short Gamma-Ray Burst 170817A and off-axis angle constraints. Monthly Notices of the Royal Astronomical Society, 476(1), 1191-1197. doi:10.1093/mnras/sty285Caleb, M., Flynn, C., Bailes, M., Barr, E. D., Bateman, T., Bhandari, S., … Krishnan, V. V. (2016). Fast Radio Transient searches with UTMOST at 843 MHz. Monthly Notices of the Royal Astronomical Society, 458(1), 718-725. doi:10.1093/mnras/stw109Caleb, M., Flynn, C., Bailes, M., Barr, E. D., Bateman, T., Bhandari, S., … Venkatraman Krishnan, V. (2017). The first interferometric detections of fast radio bursts. Monthly Notices of the Royal Astronomical Society, 468(3), 3746-3756. doi:10.1093/mnras/stx638Cao, X.-F., & Yu, Y.-W. (2018). Superconducting cosmic string loops as sources for fast radio bursts. Physical Review D, 97(2). doi:10.1103/physrevd.97.023022Champion, D. J., Petroff, E., Kramer, M., Keith, M. J., Bailes, M., Barr, E. D., … Lyne, A. G. (2016). Five new fast radio bursts from the HTRU high-latitude survey at Parkes: first evidence for two-component bursts. Monthly Notices of the Royal Astronomical Society: Letters, 460(1), L30-L34. doi:10.1093/mnrasl/slw069Chatterjee, S., Law, C. J., Wharton, R. S., Burke-Spolaor, S., Hessels, J. W. T., Bower, G. C., … van Langevelde, H. J. (2017). A direct localization of a fast radio burst and its host. Nature, 541(7635), 58-61. doi:10.1038/nature20797Cordes, J. M., & Wasserman, I. (2016). Supergiant pulses from extragalactic neutron stars. Monthly Notices of the Royal Astronomical Society, 457(1), 232-257. doi:10.1093/mnras/stv2948DeLaunay, J. J., Fox, D. B., Murase, K., Mészáros, P., Keivani, A., Messick, C., … Turley, C. F. (2016). DISCOVERY OF A TRANSIENT GAMMA-RAY COUNTERPART TO FRB 131104. The Astrophysical Journal, 832(1), L1. doi:10.3847/2041-8205/832/1/l1Dey, R. K., Ray, S., & Dam, S. (2016). Searching for PeV neutrinos from photomeson interactions in magnetars. EPL (Europhysics Letters), 115(6), 69002. doi:10.1209/0295-5075/115/69002Fahey, S., Kheirandish, A., Vandenbroucke, J., & Xu, D. (2017). A Search for Neutrinos from Fast Radio Bursts with IceCube. The Astrophysical Journal, 845(1), 14. doi:10.3847/1538-4357/aa7e28Falcke, H., & Rezzolla, L. (2014). Fast radio bursts: the last sign of supramassive neutron stars. Astronomy & Astrophysics, 562, A137. doi:10.1051/0004-6361/201321996Goldstein, A., Preece, R. D., Mallozzi, R. S., Briggs, M. S., Fishman, G. J., Kouveliotou, C., … Burgess, J. M. (2013). THE BATSE 5B GAMMA-RAY BURST SPECTRAL CATALOG. The Astrophysical Journal Supplement Series, 208(2), 21. doi:10.1088/0067-0049/208/2/21Guetta, D., Hooper, D., Alvarez-Muñiz, J., Halzen, F., & Reuveni, E. (2004). Neutrinos from individual gamma-ray bursts in the BATSE catalog. Astroparticle Physics, 20(4), 429-455. doi:10.1016/s0927-6505(03)00211-1Hümmer, S., Rüger, M., Spanier, F., & Winter, W. (2010). SIMPLIFIED MODELS FOR PHOTOHADRONIC INTERACTIONS IN COSMIC ACCELERATORS. The Astrophysical Journal, 721(1), 630-652. doi:10.1088/0004-637x/721/1/630Hümmer, S., Baerwald, P., & Winter, W. (2012). Neutrino Emission from Gamma-Ray Burst Fireballs, Revised. Physical Review Letters, 108(23). doi:10.1103/physrevlett.108.231101Johnston, S., Taylor, R., Bailes, M., Bartel, N., Baugh, C., Bietenholz, M., … Wolleben, M. (2008). Science with ASKAP. Experimental Astronomy, 22(3), 151-273. doi:10.1007/s10686-008-9124-7Katz, J. I. (2014). Coherent emission in fast radio bursts. Physical Review D, 89(10). doi:10.1103/physrevd.89.103009Keane, E. F., Johnston, S., Bhandari, S., Barr, E., Bhat, N. D. R., Burgay, M., … Bassa, C. (2016). The host galaxy of a fast radio burst. Nature, 530(7591), 453-456. doi:10.1038/nature17140Li, X., Zhou, B., He, H.-N., Fan, Y.-Z., & Wei, D.-M. (2014). MODEL-DEPENDENT ESTIMATE ON THE CONNECTION BETWEEN FAST RADIO BURSTS AND ULTRA HIGH ENERGY COSMIC RAYS. The Astrophysical Journal, 797(1), 33. doi:10.1088/0004-637x/797/1/33Lorimer, D. R., Bailes, M., McLaughlin, M. A., Narkevic, D. J., & Crawford, F. (2007). A Bright Millisecond Radio Burst of Extragalactic Origin. Science, 318(5851), 777-780. doi:10.1126/science.1147532Lyubarsky, Y. (2014). A model for fast extragalactic radio bursts. Monthly Notices of the Royal Astronomical Society: Letters, 442(1), L9-L13. doi:10.1093/mnrasl/slu046Marcote, B., Paragi, Z., Hessels, J. W. T., Keimpema, A., Langevelde, H. J. van, Huang, Y., … Wharton, R. S. (2017). The Repeating Fast Radio Burst FRB 121102 as Seen on Milliarcsecond Angular Scales. The Astrophysical Journal, 834(2), L8. doi:10.3847/2041-8213/834/2/l8Murase, K., & Nagataki, S. (2006). High energy neutrino emission and neutrino background from gamma-ray bursts in the internal shock model. Physical Review D, 73(6). doi:10.1103/physrevd.73.063002Murase, K., Kashiyama, K., & Mészáros, P. (2016). A burst in a wind bubble and the impact on baryonic ejecta: high-energy gamma-ray flashes and afterglows from fast radio bursts and pulsar-driven supernova remnants. Monthly Notices of the Royal Astronomical Society, 461(2), 1498-1511. doi:10.1093/mnras/stw1328Murase, K., Mészáros, P., & Fox, D. B. (2017). Fast Radio Bursts with Extended Gamma-Ray Emission? The Astrophysical Journal, 836(1), L6. doi:10.3847/2041-8213/836/1/l6Palaniswamy, D., Wayth, R. B., Trott, C. M., McCallum, J. N., Tingay, S. J., & Reynolds, C. (2014). A SEARCH FOR FAST RADIO BURSTS ASSOCIATED WITH GAMMA-RAY BURSTS. The Astrophysical Journal, 790(1), 63. doi:10.1088/0004-637x/790/1/63Palmer, D. M., Barthelmy, S., Gehrels, N., Kippen, R. M., Cayton, T., Kouveliotou, C., … Tueller, J. (2005). A giant γ-ray flare from the magnetar SGR 1806–20. Nature, 434(7037), 1107-1109. doi:10.1038/nature03525Pen, U.-L., & Connor, L. (2015). LOCAL CIRCUMNUCLEAR MAGNETAR SOLUTION TO EXTRAGALACTIC FAST RADIO BURSTS. The Astrophysical Journal, 807(2), 179. doi:10.1088/0004-637x/807/2/179Petroff, E., Johnston, S., Keane, E. F., van Straten, W., Bailes, M., Barr, E. D., … Stappers, B. W. (2015). A survey of FRB fields: limits on repeatability. Monthly Notices of the Royal Astronomical Society, 454(1), 457-462. doi:10.1093/mnras/stv1953Petroff, E., Bailes, M., Barr, E. D., Barsdell, B. R., Bhat, N. D. R., Bian, F., … Wolf, C. (2014). A real-time fast radio burst: polarization detection and multiwavelength follow-up. Monthly Notices of the Royal Astronomical Society, 447(1), 246-255. doi:10.1093/mnras/stu2419Petroff, E., Barr, E. D., Jameson, A., Keane, E. F., Bailes, M., Kramer, M., … van Straten, W. (2016). FRBCAT: The Fast Radio Burst Catalogue. Publications of the Astronomical Society of Australia, 33. doi:10.1017/pasa.2016.35Ravi, V., & Lasky, P. D. (2014). The birth of black holes: neutron star collapse times, gamma-ray bursts and fast radio bursts. Monthly Notices of the Royal Astronomical Society, 441(3), 2433-2439. doi:10.1093/mnras/stu720Ravi, V., Shannon, R. M., & Jameson, A. (2015). A FAST RADIO BURST IN THE DIRECTION OF THE CARINA DWARF SPHEROIDAL GALAXY. The Astrophysical Journal, 799(1), L5. doi:10.1088/2041-8205/799/1/l5Scholz, P., Spitler, L. G., Hessels, J. W. T., Chatterjee, S., Cordes, J. M., Kaspi, V. M., … Tendulkar, S. P. (2016). THE REPEATING FAST RADIO BURST FRB 121102: MULTI-WAVELENGTH OBSERVATIONS AND ADDITIONAL BURSTS. The Astrophysical Journal, 833(2), 177. doi:10.3847/1538-4357/833/2/177Scholz, P., Bogdanov, S., Hessels, J. W. T., Lynch, R. S., Spitler, L. G., Bassa, C. G., … Wharton, R. S. (2017). Simultaneous X-Ray, Gamma-Ray, and Radio Observations of the Repeating Fast Radio Burst FRB 121102. The Astrophysical Journal, 846(1), 80. doi:10.3847/1538-4357/aa8456Spitler, L. G., Scholz, P., Hessels, J. W. T., Bogdanov, S., Brazier, A., Camilo, F., … Zhu, W. W. (2016). A repeating fast radio burst. Nature, 531(7593), 202-205. doi:10.1038/nature17168Tendulkar, S. P., Bassa, C. G., Cordes, J. M., Bower, G. C., Law, C. J., Chatterjee, S., … Wharton, R. S. (2017). The Host Galaxy and Redshift of the Repeating Fast Radio Burst FRB 121102. The Astrophysical Journal, 834(2), L7. doi:10.3847/2041-8213/834/2/l7Thornton, D., Stappers, B., Bailes, M., Barsdell, B., Bates, S., Bhat, N. D. R., … van Straten, W. (2013). A Population of Fast Radio Bursts at Cosmological Distances. Science, 341(6141), 53-56. doi:10.1126/science.1236789Totani, T. (2013). Cosmological Fast Radio Bursts from Binary Neutron Star Mergers. Publications of the Astronomical Society of Japan, 65(5), L12. doi:10.1093/pasj/65.5.l12Wang, J.-S., Yang, Y.-P., Wu, X.-F., Dai, Z.-G., & Wang, F.-Y. (2016). FAST RADIO BURSTS FROM THE INSPIRAL OF DOUBLE NEUTRON STARS. The Astrophysical Journal, 822(1), L7. doi:10.3847/2041-8205/822/1/l7Waxman, E., & Bahcall, J. (1997). High Energy Neutrinos from Cosmological Gamma-Ray Burst Fireballs. Physical Review Letters, 78(12), 2292-2295. doi:10.1103/physrevlett.78.2292Ye, J., Wang, K., & Cai, Y.-F. (2017). Superconducting cosmic strings as sources of cosmological fast radio bursts. The European Physical Journal C, 77(11). doi:10.1140/epjc/s10052-017-5319-2Zhang, B. (2013). A POSSIBLE CONNECTION BETWEEN FAST RADIO BURSTS AND GAMMA-RAY BURSTS. The Astrophysical Journal, 780(2), L21. doi:10.1088/2041-8205/780/2/l21Zhang, B., & Kumar, P. (2013). Model-Dependent High-Energy Neutrino Flux from Gamma-Ray Bursts. Physical Review Letters, 110(12). doi:10.1103/physrevlett.110.121101Zhang, B., Xu, R. X., & Qiao, G. J. (2000). Nature and Nurture: a Model for Soft Gamma-Ray Repeaters. The Astrophysical Journal, 545(2), L127-L130. doi:10.1086/317889Zhang, B., Dai, Z. G., Meszaros, P., Waxman, E., & Harding, A. K. (2003). High‐Energy Neutrinos from Magnetars. The Astrophysical Journal, 595(1), 346-351. doi:10.1086/37719

The First Post-Kepler Brightness Dips of KIC 8462852

We present a photometric detection of the first brightness dips of the unique variable star KIC 8462852 since the end of the Kepler space mission in 2013 May. Our regular photometric surveillance started in October 2015, and a sequence of dipping began in 2017 May continuing on through the end of 2017, when the star was no longer visible from Earth. We distinguish four main 1-2.5% dips, named "Elsie," "Celeste," "Skara Brae," and "Angkor", which persist on timescales from several days to weeks. Our main results so far are: (i) there are no apparent changes of the stellar spectrum or polarization during the dips; (ii) the multiband photometry of the dips shows differential reddening favoring non-grey extinction. Therefore, our data are inconsistent with dip models that invoke optically thick material, but rather they are in-line with predictions for an occulter consisting primarily of ordinary dust, where much of the material must be optically thin with a size scale <<1um, and may also be consistent with models invoking variations intrinsic to the stellar photosphere. Notably, our data do not place constraints on the color of the longer-term "secular" dimming, which may be caused by independent processes, or probe different regimes of a single process

Observation of the cosmic ray shadow of the Sun with the ANTARES neutrino telescope

[EN] The ANTARES detector is an undersea neutrino telescope in the Mediterranean Sea. The search for pointlike neutrino sources is one of the main goals of the ANTARES telescope, requiring a reliable method to evaluate the detector angular resolution and pointing accuracy. This work describes the study of the Sun ¿shadow¿ effect with the ANTARES detector. The shadow is the deficit in the atmospheric muon flux in the direction of the Sun caused by the absorption of the primary cosmic rays. This analysis is based on the data collected between 2008 and 2017 by the ANTARES telescope. The observed statistical significance of the Sun shadow detection is 3.7¿, with an estimated angular resolution of 0.59° +- 0.10°for downward-going muons. The pointing accuracy is found to be consistent with the expectations and no evidence of systematic pointing shifts is observed.The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique, Commissariat `a l'' energie atomique et aux energies alternatives, Commission Europeenne (FEDER fund and Marie Curie Program), Institut Universitaire de France, LabEx UnivEarthS (ANR-10-LABX-0023 and ANR-18-IDEX-0001), R ' egion Ile-de-France (DIM-ACAV), Region Alsace (contract CPER), Region Provence-Alpes-Cote d'Azur, Departement du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium fur Bildung und Forschung, Germany; Istituto Nazionale di Fisica Nucleare, Italy; Nederlandse organisatie voor Wetenschappelijk Onderzoek, the Netherlands; Council of the President of the Russian Federation for Young Scientists and Leading Scientific Schools supporting grants, Russia; Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI), Romania; Ministerio de Ciencia, Innovacion, Investigacion y Universidades (MCIU): Programa Estatal de Generacion de Conocimiento (refs. PGC2018-096663-B-C41, -A-C42, -B-C43, -B-C44) (MCIU/FEDER), Severo Ochoa Centre of Excellence and MultiDark Consolider (MCIU), Junta de Andalucia (refs. SOMM17/6104/UGR and A-FQM-053-UGR18), Generalitat Valenciana: Grisolia (ref. GRISOLIA/2018/119), Spain; Ministry of Higher Education, Scientific Research and Professional Training, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.Albert, A.; Andre, M.; Anghinolfi, M.; Anton, G.; Ardid Ramírez, M.; Aubert, J.; Aublin, J.... (2020). Observation of the cosmic ray shadow of the Sun with the ANTARES neutrino telescope. Physical Review D: covering particles, fields, gravitation, and cosmology. 102(12):1-7. https://doi.org/10.1103/PhysRevD.102.122007S1710212Ageron, M., Aguilar, J. A., Al Samarai, I., Albert, A., Ameli, F., André, M., … Ardid, M. (2011). ANTARES: The first undersea neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 656(1), 11-38. doi:10.1016/j.nima.2011.06.103Alexandreas, D. E., Allen, R. C., Berley, D., Biller, S. D., Burman, R. L., Cady, D. R., … Zhang, W. (1991). Observation of shadowing of ultrahigh-energy cosmic rays by the Moon and the Sun. Physical Review D, 43(5), 1735-1738. doi:10.1103/physrevd.43.1735Andreyev, Y. M., Zakidyshev, V. N., Karpov, S. N., & Khodov, V. N. (2002). Cosmic Research, 40(6), 559-564. doi:10.1023/a:1021553713199Borione, A., Catanese, M., Covault, C. E., Cronin, J. W., Fick, B. E., Gibbs, K. G., … van der Velde, J. C. (1994). Observation of the shadows of the Moon and Sun using 100 TeV cosmic rays. Physical Review D, 49(3), 1171-1177. doi:10.1103/physrevd.49.1171Cobb, J. H., Marshak, M. L., Allison, W. W. M., Alner, G. J., Ayres, D. S., Barrett, W. L., … Wall, D. (2000). Observation of a shadow of the Moon in the underground muon flux in the Soudan 2 detector. Physical Review D, 61(9). doi:10.1103/physrevd.61.092002Bartoli, B., Bernardini, P., Bi, X. J., Bleve, C., Bolognino, I., Branchini, P., … Cao, Z. (2012). Measurement of the cosmic ray antiproton/proton flux ratio at TeV energies with the ARGO-YBJ detector. Physical Review D, 85(2). doi:10.1103/physrevd.85.022002Abeysekara, A. U., Albert, A., Alfaro, R., Alvarez, C., Álvarez, J. D., Arceo, R., … Belmont-Moreno, E. (2018). Constraining the p¯/p ratio in TeV cosmic rays with observations of the Moon shadow by HAWC. Physical Review D, 97(10). doi:10.1103/physrevd.97.102005Adamson, P., Andreopoulos, C., Ayres, D. S., Backhouse, C., Barr, G., Barrett, W. L., … Bock, G. J. (2011). Observation in the MINOS far detector of the shadowing of cosmic rays by the sun and moon. Astroparticle Physics, 34(6), 457-466. doi:10.1016/j.astropartphys.2010.10.010Aartsen, M. G., Ackermann, M., Adams, J., Aguilar, J. A., Ahlers, M., Ahrens, M., … Ansseau, I. (2019). Detection of the Temporal Variation of the Sun’s Cosmic Ray Shadow with the IceCube Detector. The Astrophysical Journal, 872(2), 133. doi:10.3847/1538-4357/aaffd1Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Barrios-Martít, J. (2018). The cosmic ray shadow of the Moon observed with the ANTARES neutrino telescope. The European Physical Journal C, 78(12). doi:10.1140/epjc/s10052-018-6451-3First search for neutrinos in correlation with gamma-ray bursts with the ANTARES neutrino telescope. (2013). Journal of Cosmology and Astroparticle Physics, 2013(03), 006-006. doi:10.1088/1475-7516/2013/03/006Aguilar, J. A., Al Samarai, I., Albert, A., André, M., Anghinolfi, M., Anton, G., … Astraatmadja, T. (2011). A fast algorithm for muon track reconstruction and its application to the ANTARES neutrino telescope. Astroparticle Physics, 34(9), 652-662. doi:10.1016/j.astropartphys.2011.01.003BECHERINI, Y., MARGIOTTA, A., SIOLI, M., & SPURIO, M. (2006). A parameterisation of single and multiple muons in the deep water or ice. Astroparticle Physics, 25(1), 1-13. doi:10.1016/j.astropartphys.2005.10.005Carminati, G., Bazzotti, M., Margiotta, A., & Spurio, M. (2008). Atmospheric MUons from PArametric formulas: a fast GEnerator for neutrino telescopes (MUPAGE). Computer Physics Communications, 179(12), 915-923. doi:10.1016/j.cpc.2008.07.014Yepes-Ramírez, H. (2013). Characterization of optical properties of the site of the ANTARES neutrino telescope. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 725, 203-206. doi:10.1016/j.nima.2012.11.143Fusco, L. A., & Margiotta, A. (2016). The Run-by-Run Monte Carlo simulation for the ANTARES experiment. EPJ Web of Conferences, 116, 02002. doi:10.1051/epjconf/201611602002Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Basa, S. (2017). First all-flavor neutrino pointlike source search with the ANTARES neutrino telescope. Physical Review D, 96(8). doi:10.1103/physrevd.96.082001Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., Aubert, J.-J., … Belhorma, B. (2020). ANTARES and IceCube Combined Search for Neutrino Point-like and Extended Sources in the Southern Sky. The Astrophysical Journal, 892(2), 92. doi:10.3847/1538-4357/ab7afbAdrián-Martínez, S., Albert, A., André, M., Anghinolfi, M., Anton, G., Ardid, M., … Basa, S. (2014). SEARCHES FOR POINT-LIKE AND EXTENDED NEUTRINO SOURCES CLOSE TO THE GALACTIC CENTER USING THE ANTARES NEUTRINO TELESCOPE. The Astrophysical Journal, 786(1), L5. doi:10.1088/2041-8205/786/1/l